February 3, 2023
Meso Scale Discovery

Meso Scale Discovery (MSD) was founded in 1995 and has emerged as a global leader in the successful buildout, creation, and sales of new assays and instruments for quantifying molecules in biological specimens, sometime after the introduction to drug discovery and development. The technology used by MSD has been accepted worldwide due to increased sensitivity, high quality of reproducibility, etc.

The four imperative Meso Scale Discovery techniques are as follows:

1. Immunoassay technology

They are mostly sandwich designs that measure the number of specific molecules in complex biological samples.

It provides unparalleled analytical performance and customer value. This technology can be used for many biomedical and pharmaceutical research purposes, leading to many drug discovery pathways. Immunoassay technology provides efficiency along with increased sensitivity and accuracy. The results produced by this technology are highly reliable. The Meso Scale Discovery (MSD) Assay Platform outperforms standard ELISA in various ways. MSD ELISA tests, on average, have superior sensitivity and accuracy, a wider dynamic range (3-4 logs), and a smaller background signal than traditional ELISAs. The capacity to create unique MesoScale Discovery multiplex panels for quantitating up to 10 analytes per well utilizing tiny sample quantities (25 uL) is a significant benefit. Multiple Analytes are quantified simultaneously from a single, small-volume sample using the highly beneficial MULTI-SPOT panels.

2. Electrochemiluminescence

Electrochemiluminescent labels produce light when stimulated by electricity in the appropriate chemical environment. The Meso scale discovery Immunoassays utilize this reaction to generate the light signal that can be used to quantify the critical  biomedical molecules further. 

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The following are the advantages of using meso scale discovery electrochemiluminescence:

Increased sensitivity due to the various excitations rounds that amplify signals to better the light levels

Both High and low levels of molecules can be measured without multiple sample dilutions, indicating a very dynamic range of detection.

Since the stimulation mechanism (electricity) is dissociated from the signal, only labels near the electrode surface may be recognized (light).

3. MULTI-ARRAY technology 

MULTI-ARRAY technology is a combination of electrochemiluminescence and arrays. This technology produces a high density of data for biological assays. This technology makes Accurate measurements of several analytics of one sample using the MULTI-SPOT plates. These plates can provide assays in 96- and 384-well formats and up to 10 spots per well. The results are produced quicker and with fewer efforts than in other assay applications.

The following are the advantages of using the MULTI-ARRAY technology:

  • It produces different results using one sample, saving important and valuable models.
  • The conventional single-analytic assays are usually low on sensitivity and speed, but this technology using single sample analytics only produces increased rate and precision results.
  • Using this technology, quantifying native levels of biomarkers can be done in normal and diseased samples without multiple dilutions.

4. Meso scale discovery assay instruments 

MSD has instruments to suit any application, budget, or research environment. Some famous tools include the MESO SECTOR S 600, ideal for programs that demand increased data content and high throughput. The MESO QuickPlex SQ 120 is another MSD instrument that provides a small, low-cost spread spectrum imager with high performance.

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All the Meso scale discovery assay instruments use the enhanced MULTI-ARRAY technology and the Assay assessment software, DISCOVERY WORKBENCH, that produces well-organized results. The MESO Scale discovery with these innovative technologies has enabled quicker and more efficient biological analysis, which has further aided our scientific community with research and development.

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